![]() ![]() Patients receiving the operation before June 2005 (19 cases) and after (22 cases) were compared the improvements in UPDRS part III were 13.2% and 55.2%, respectively (P<0.001). Most of the structural improvement occurred before mid-2005. The deep brain stimulation protocol evolved and was substantiated by updated patient selection criteria and outcome assessment, integrated imaging and neurophysiological targeting, refinement of surgical technique as well as the accumulation of experience in deep brain stimulation programming. Throughout the years, a multidisciplinary team was gradually built. ![]() For the whole group, the mean improvements of Unified Parkinson’s Disease Rating Scale (UPDRS) parts II and III were 32.5% and 31.5%, respectively (P<0.001). Forty-one patients (21 male and 20 female) with Parkinson’s disease underwent bilateral subthalamic nucleus deep brain stimulation and were followed up for a median interval of 12 months. ![]()
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